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Consequently, this impairment results in decreased serotonin synthesis and reduced availability of this critical neurotransmitter

The closest thing to an evidence-based loose skin protocol is: adequate protein, resistance training, gradual weight loss when possible, sun protection, retinoids for facial use, topical GHK-Cu as adjunct, hydration, and patience

Metabolism Rate: Faster metabolism may lead to quicker results but may also require more frequent dosing

Serious Conditions (for which you would seek professional help.) Examples: A painful and swollen ankle that you cannot place any weight on at all, or a sore and red throat that makes eating or drinking difficult